THERAPEUTIC CLASS

Targeted Deletion of the Sclerostin Gene in Mice Results in Increase Bone Formation and Bone Strength

---

Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations
in SOST, the gene encoding sclerostin. Based on these data, sclerostin has emerged as a key negative
regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of
the effects of sclerostin deficiency on bone

---

Availability

Detail Information

Series Title

-

Call Number

-

Publisher

: .,

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

LITERATURE

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Musculo-Skeletal System

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment