Image of Targeted Deletion of the Sclerostin Gene in Mice Results in Increase Bone Formation and Bone Strength

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Targeted Deletion of the Sclerostin Gene in Mice Results in Increase Bone Formation and Bone Strength


Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations
in SOST, the gene encoding sclerostin. Based on these data, sclerostin has emerged as a key negative
regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of
the effects of sclerostin deficiency on bone


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English
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