THERAPEUTIC CLASS
Subclinical Hypothyroidism
A 71-year-old woman reports fatigue and mild depression. She has hypertension and
had a myocardial infarction 4 years ago. She has a family history of autoimmune
thyroid disease. The physical examination is unremarkable. No thyroid enlargement
is present. Laboratory results include normal levels of hemoglobin, creatinine,
and calcium and a normal erythrocyte sedimentation rate. The thyrotropin level is
6.9 mIU per liter (reference range, 0.4 to 4.3), whereas the free thyroxine (T4) level
is normal (19 pmol per liter; reference range, 11 to 25). How should she be further
evaluated and her symptoms managed?
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