THERAPEUTIC CLASS

New agents to reduce cholesterol levels: implications for nephrologists

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Statins and ezetimibe effectively reduce the burden of cardiovascular (CV) disease in patients with chronic kidney disease (CKD). Unfortunately, many subjects still die or have CV events despite cholesterol-lowering therapy. This is particularly true in patients with more advanced CKD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that induces the degradation of the low-density lipoprotein receptor by targeting
it for lysosomal destruction

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: .,

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Language

English

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NONE

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Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

Nephrol Dial Transplant (2019) 1–6

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