PRODUCT LITERATURE

Latanoprost in the treatment of glaucoma

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Prostaglandins are approved by the European Glaucoma Society guidelines as first-line treatment for glaucoma. This review focuses on latanoprost, an ester prodrug of prostaglandin (PG) F2α, which was the first of the currently available topical PGF2α analogs to be launched for glaucoma or ocular hypertension and which still accounts for the majority of prescriptions. It is better absorbed than the parent compound through the cornea, and peak concentration of the active drug is in the aqueous humor 1–2 hours after topical dosing (15–30 ng/mL). Metabolism occurs mainly in the liver.

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Detail Information

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Language

English

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NONE

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Subject(s)

Lacoma

Specific Detail Info

Clinical Ophthalmology 2014:8 1967–1985

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