PRODUCT LITERATURE

Thermosensitive chitosan–Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration

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Injectable hydrogels have been studied for potential applications for articular cartilage regeneration. In this study, a thermosensitive
chitosan–Pluronic (CP) hydrogel was designed as an injectable cell delivery carrier for cartilage regeneration. The CP conjugate was synthesized
by grafting Pluronic onto chitosan using EDC/NHS chemistry. The sol–gel phase transition and mechanical properties of the CP
hydrogel were examined by rheological experiments. The CP solution underwent a sol–gel transition around 25 C at which the storage
modulus (G0) approaches 104 Pa, highlighting the potential of this material as an injectable scaffold for cartilage regenerationInjectable hydrogels have been studied for potential applications for articular cartilage regeneration. In this study, a thermosensitive
chitosan–Pluronic (CP) hydrogel was designed as an injectable cell delivery carrier for cartilage regeneration. The CP conjugate was synthesized
by grafting Pluronic onto chitosan using EDC/NHS chemistry. The sol–gel phase transition and mechanical properties of the CP
hydrogel were examined by rheological experiments. The CP solution underwent a sol–gel transition around 25 C at which the storage
modulus (G0) approaches 104 Pa, highlighting the potential of this material as an injectable scaffold for cartilage regeneration

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: .,

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Mediclore

Specific Detail Info

Acta Biomaterialia 5 (2009) 1956–1965

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