Image of Transition Metal Mediated Release of Nitric Oxide (NO) from S-Nitroso- N-acetylpenicillamine (SNAP): Potential Applications for Endogenous
Release of NO on the Surface of Stents via Corrosion Products

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Transition Metal Mediated Release of Nitric Oxide (NO) from S-Nitroso- N-acetylpenicillamine (SNAP): Potential Applications for Endogenous Release of NO on the Surface of Stents via Corrosion Products


Nitric oxide (NO), identified over the last several decades in many physiological processes and pathways as both a beneficial and detrimental signaling molecule, has been the subject of extensive research. Physiologically, NO is transported by a class of donors known as S-nitrosothiols. Both endogenous and synthetic S-nitrosothiols have been reported to release NO during interactions with certain transition metals, primarily Cu2+ and Fe2+. Ag+ and Hg2+ have also been identified, although these metals are not abundantly present in physiological systems


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