THERAPEUTIC CLASS

Transition Metal Mediated Release of Nitric Oxide (NO) from S-Nitroso- N-acetylpenicillamine (SNAP): Potential Applications for Endogenous Release of NO on the Surface of Stents via Corrosion Products

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Nitric oxide (NO), identified over the last several decades in many physiological processes and pathways as both a beneficial and detrimental signaling molecule, has been the subject of extensive research. Physiologically, NO is transported by a class of donors known as S-nitrosothiols. Both endogenous and synthetic S-nitrosothiols have been reported to release NO during interactions with certain transition metals, primarily Cu2+ and Fe2+. Ag+ and Hg2+ have also been identified, although these metals are not abundantly present in physiological systems

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: .,

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English

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NONE

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Subject(s)

Respiratory system

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