THERAPEUTIC CLASS

β-Thalassemia

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β-Thalassemia is caused by reduced (β+) or absent (β0) synthesis of the β-globin chains of hemoglobin. Three clinical and hematological conditions of increasing severity are recognized: the β-thalassemia carrier state, thalassemia intermedia, and thalassemia major, a severe transfusion-dependent anemia. The severity of disease expression is related mainly to the degree of α-globin chain excess, which precipitates in the red blood cell precursors, causing both mechanic and oxidative damage (ineffective erythropoiesis).

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

Therapeutic Class

Media Type

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Carrier Type

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Edition

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Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

Genetics in meDicine | Volume 19 | Number 6 | June 2017

Statement of Responsibility

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