THERAPEUTIC CLASS

Pressure gradient vs. flow relationships to characterize the physiology of a severely stenotic aortic valve before and after transcatheter valve implantation

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Pressure loss vs. flow curves offer a fundamental fluid dynamic synthesis for describing aortic valve pathophysiology.
Severe AS does not consistently behave like an orifice (as suggested by Gorlin) or a resistor, whereas TAVI
devices behave like a pure resistor. During peak dobutamine, the ratio of aortic to left ventricular pressures during
systolic ejection provides a ‘fractional flow reserve’ of the aortic valve that closely approximates the complex,
changing fluid dynamics. Because resting assessment cannot reliably predict stress haemodynamics, ‘valvular fractional
flow’ warrants study to explain exertional symptoms in patients with only moderate AS at rest

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Publisher

: .,

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Language

English

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NONE

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Subject(s)

Cardiovascular & Hematopoietic System
NTG
Dobuject

Specific Detail Info

European Heart Journal (2018) 39, 2646–2655

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