THERAPEUTIC CLASS
Gas exchange and ventilation–perfusion relationships in the lung
While the healthy lung efficiently exchanges respiratory gases, hypoxaemia and hypercapnia indicate
pathophysiology and failure of the lung to provide adequate gas exchange. An understanding of how gases
are transferred and the causes of inefficient gas exchange are central to caring for patients with lung diseases.
In this article, we will review the normal and pathological mechanisms of gas exchange. Starting with simple
and building to more complex, we will emphasise basic concepts and relate them to case scenarios familiar
to clinicians.
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