THERAPEUTIC CLASS

Bevacizumab prevents brain metastases formation in lung adenocarcinoma

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Patients with non-squamous non-small cell lung cancer (nsNSCLC; largely lung adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti-VEGF-A therapy may prevent the formation of nsNSCLC brain metastases. Whether non-brain metastases are also prevented, and whether bevacizumab shows a brain metastases preventive activity in cancer patients is unknown. Data of one nsNSCLC (stage IIIB/IV, AVAiL) and two breast cancer bevacizumab trials (HER2 negative, AVADO; HER2 positive, AVEREL) were retrospectively analysed regarding the frequency of the brain vs. other organs
being the site of first relapse.

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: .,

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English

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NONE

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Oncology

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