THERAPEUTIC CLASS

Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function

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Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting their function may be a novel therapeutic approach. The present study used a mouse model of asthma to demonstrate that transplantation of MSCs suppressed features of asthma by targeting the function of lung myeloid DCs

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: .,

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Language

English

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NONE

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Subject(s)

Respiratory system

Specific Detail Info

MOLECULAR MEDICINE REPORTS 12: 2511-2520, 2015

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