THERAPEUTIC CLASS

Dual roles of yes-associated protein (YAP) in colorectal cancer

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Yes-associated protein (YAP) is a downstream effector molecule of a newly emerging tumour suppressor pathway called the Hippo pathway. YAP is a transcriptional co-activator and mis-expressed in various cancers, including colorectal
cancer (CRC). Accumulating studies show that the high expression of nuclear YAP is linked with tumour progression and decreased survival. Nuclear YAP can interact with other transcription factors to promote cancer cell proliferation, apoptosis, metastasis and maintenance of stemness

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: .,

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Language

English

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NONE

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Subject(s)

Oncology

Specific Detail Info

Oncotarget, 2017, Vol. 8, (No. 43), pp: 75727-75741

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