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LITERATURE

Renin-Angiotensin-Aldosterone System and Progression of Renal Disease


Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful maneuvers to slow progression
of renal disease. Angiotensin II (AngII) has emerged in the past decade as a multifunctional cytokine that exhibits many
nonhemodynamic properties, such as acting as a growth factor and profibrogenic cytokine, and even having proinflammatory
properties. Many of these deleterious functions are mediated by other factors, such as TGF- and chemoattractants that are
induced in the kidney by AngII.


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REQJ607-02Titan CenterAvailable

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English
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NONE
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J Am Soc Nephrol 17: 2985–2991
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