THERAPEUTIC CLASS

Renin-Angiotensin-Aldosterone System and Progression of Renal Disease

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Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful maneuvers to slow progression
of renal disease. Angiotensin II (AngII) has emerged in the past decade as a multifunctional cytokine that exhibits many
nonhemodynamic properties, such as acting as a growth factor and profibrogenic cytokine, and even having proinflammatory
properties. Many of these deleterious functions are mediated by other factors, such as TGF-
and chemoattractants that are
induced in the kidney by AngII.

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: .,

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Language

English

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NONE

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Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

J Am Soc Nephrol 17: 2985–2991

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