THERAPEUTIC CLASS

Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity

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An accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide, is critically needed for
surveillance and treatment management. Past attempts failed to reliably detect the mycobacterial glycan antigen
lipoarabinomannan (LAM), a marker of active TB, in HIV-negative, pulmonary TB–infected patients’ urine (85% of
9.6 million patients). We apply a copper complex dye within a hydrogel nanocage that captures LAM with very
high affinity, displacing interfering urine proteins.

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: .,

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Language

English

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NONE

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Subject(s)

Other Therapeutic Class

Specific Detail Info

Sci. Transl. Med. 9, eaal2807 (2017

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