THERAPEUTIC CLASS

Clinical effectiveness of cell therapies in patients with chronic liver disease and acute-on-chronic liver failure: a systematic review protocol

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Chronic liver disease (CLD) is a major health burden worldwide. Liver cirrhosis, a form of CLD is the
fifth most common cause of death in the UK. Acute-on-chronic liver failure (ACLF) is the result of an acute insult
superimposed on patients with liver cirrhosis as a result of precipitating events such as infection or bleeding. ACLF
has a high associated mortality as a result of multi-organ failure. The only effective treatment for CLD is liver
transplantation, but the treatment is limited by shortage of donor organs. As a result, alternative treatments such as
cell therapies have been studied in patients with liver diseases. This study will systematically review the evidence on
clinical effectiveness of cell therapies in patients

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Detail Information

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: .,

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Language

English

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Classification

NONE

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Subject(s)

SNMC
Gastrointestinal & Hepatobiliary System

Specific Detail Info

Systematic Reviews (2016) 5:100

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