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LITERATURE

Natural Antibodies Bridge Innate and Adaptive Immunity


Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen elimination, B cell survival and homeostasis, inflammatory diseases, and autoimmunity, there is a lack of clarity about the physiological role of natural IgG and natural IgA because they appear
incapable of recognizing Ags on their own and are perceived as nonreactive


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REQJ561-004Titan CenterAvailable

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English
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NONE
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Specific Detail Info
The Journal of Immunology, 2015, 194: 13–20
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