THERAPEUTIC CLASS

Angiotensin II and skeletal muscle abnormalities

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The renin–angiotensin system (RAS) is known to be activated systemically and in local organs in cardiovascular disease,
metabolic disease and other chronic diseases, as well as with age. This activation is strongly associated with organ
damage. Many studies have reported the role of RAS activation in cardiovascular disease, and angiotensin II (Ang II) in
particular has been identified as a player in the development of heart failure with accompanying mitochondrial dysfunction.
In fact, RAS inhibitors are in clinical use, and much evidence has been reported for improved outcomes with their use in
patients with heart failure.

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

Circ Res 108, 837–846

Statement of Responsibility

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