THERAPEUTIC CLASS

Pathogenesis of Gastric Cancer

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Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. GC is a heterogeneous disease and the endpoint of a long multistep process largely influenced by Helicobacter pylori infection, genetic susceptibility, and environmental factors. In a subset of GC cases, infection with the Epstein–Barr virus (EBV) may also be
involved. The development of GC is the consequence of the accumulation of multiple epi/genetic changes during the patient’s lifetime that will result in oncogenic activation and/or tumor suppressor pathways’ inactivation.

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Publisher

: .,

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Oncology

Specific Detail Info

Helicobacter 20 (Suppl. S1): 30–35

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