THERAPEUTIC CLASS

The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model

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Treatment of diabetes complications remains a substantial challenge. The aim of this study was to explore the
ability of the soy isoflavone genistein in attenuating the signs that follow diabetes onset: nociceptive
hypersensitivity, oxidative and inflammatory state,nerve growth factor(NGF)decrease and vascular dysfunctions.
Genistein (3 and 6 mg/kg) was administered to C57BL/6J streptozotocin diabetic mice from the 2nd till the 5th
week after disease induction. The hind paw withdrawal threshold to mechanical stimulation (tactile allodynia)
was evaluated by a von Frey filament.

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Detail Information

Series Title

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

Therapeutic Class

Media Type

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Carrier Type

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Edition

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Subject(s)

Endocrine & Metabolic system
Eclid
Gluvas

Specific Detail Info

European Journal of Pharmacology 650 (2011) 694–702

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