Image of The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model

LITERATURE

The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model


Treatment of diabetes complications remains a substantial challenge. The aim of this study was to explore the
ability of the soy isoflavone genistein in attenuating the signs that follow diabetes onset: nociceptive
hypersensitivity, oxidative and inflammatory state,nerve growth factor(NGF)decrease and vascular dysfunctions.
Genistein (3 and 6 mg/kg) was administered to C57BL/6J streptozotocin diabetic mice from the 2nd till the 5th
week after disease induction. The hind paw withdrawal threshold to mechanical stimulation (tactile allodynia)
was evaluated by a von Frey filament.


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English
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NONE
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European Journal of Pharmacology 650 (2011) 694–702
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