CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin

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CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin

Mann L - Personal Name;

To assess the role of alveolar macrophages (AMs) during a pulmonary Aspergillus fumigatus infection AMs were depleted by intratracheal application of diphtheria toxin (DTX) to transgenic CD11c.DTR mice prior to fungal infection. Unexpectedly, all CD11c.DTR mice treated with DTX died within 4–5 days, whether being infected with A. fumigatus or not. Despite measurable impact of DTX on lung functional parameters, these constrictions
could not explain the high mortality rate. Instead, DTX-treated CD11c.DTR animals developed fulminant myocarditis (FM) characterized by massive leukocyte infiltration and myocardial cell destruction, including central parts of the heart’s stimulus transmission system

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Language: English
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Subject(s): Allergy & Immune System
Specific Detail Info: Eur. J. Immunol. 2016. 00: 1–15
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