THERAPEUTIC CLASS

Leveraging natural killer cells for cancer immunotherapy

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Natural killer (NK) cells are potent antitumor effector cells of the innate immune system. Based on their ability to eradicate tumors in vitro and in animal models, significant enthusiasm surrounds the prospect of leveraging human NK cells as vehicles for cancer immunotherapy. While interest in manipulating the effector functions of
NK cells has existed for over 30 years, there is renewed optimism for this approach today. Although T cells receive much of the clinical and preclinical attention when it comes to cancer immunotherapy, new strategies are utilizing adoptive NK-cell immunotherapy and monoclonal antibodies and engineered molecules which have
been developed to specifically activate NK cells against tumors.

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Antineoplastic

Specific Detail Info

Immunotherapy (2017) 9(6), 487–497

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