THERAPEUTIC CLASS

Tailoring Natural Killer cell immunotherapy to the tumour microenvironment

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Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity.
Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the
tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we
review the various cellular and molecular pathways that tumours have supplanted to evade NK cell surveillance.
We highlight novel strategies designed to alleviate or circumvent the immunosuppressive conditions of the
tumour microenvironment in order to emancipate NK cell function and stifle the inexorable growth and metastasis
of malignant cells

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Antineoplastic

Specific Detail Info

Seminars in Immunology

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