THERAPEUTIC CLASS

Pleiotropic Effects of Statins on the Cardiovascular System

---

The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary
mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis
thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDLcholesterol.
Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering
called pleiotropic effects. Because statins inhibit the production of isoprenoid intermediates in the cholesterol
biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins such as Rho and Rac, and
their downstream effectors such as Rho kinase and nicotinamide adenine dinucleotide phosphate oxidases are also
inhibited.

---

Availability

Detail Information

Series Title

-

Call Number

-

Publisher

: .,

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Cardiovascular & Hematopoietic System
Stator
Cholestor
Rosufer
Atorvastatin OGB

Specific Detail Info

Circ Res. 2017;120:229-243

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment