THERAPEUTIC CLASS
Fatal diphtheria myocarditis in a 3-year-old girl—related to late availability and administration of antitoxin?
Sporadic cases of diphtheria are very rare throughout Europe. A 3-year-old incompletely
vaccinated girl was admitted with pharyngotonsillitis caused by diphtheria. On day 9 of her
illness, renal and cardiac failure with a third-degree AV-block occurred. Unfortunately, she died
within 36 h of admission to intensive care, despite pacemaker placement, the administration of
antibiotics and diphtheria antitoxin. The delayed antitoxin administration 7 days after admission
to hospital was related to a lack of availability and knowledge of its availability in Europe and this
is likely to have contributed to the unfavourable outcome
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