THERAPEUTIC CLASS

Diphtheria: Clinical Manifestations, Diagnosis, and Role of ImmunizationIn Prevention

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Diphtheria outbreaks, though very rare, still occur worldwide, in the developed and developing
countries. Diphtheria has high mortality in non-vaccinated populations. Corynebacterium diphtheria produce
very potent toxin when infected with a bacteriophage that migrates the toxin-encoding genetic elements into
bacteria. The R domain binds to a cell surface receptor, permitting the toxin to enter the cell by receptor
mediated endocytosis.The toxin elaborated locally induces a dense necrotic coagulum composed of
fibrin,leukocytosis,dead respiratory epithelial cells, leading to white-gray brown pseudomembrane.,a common
cause of death is suffocation after aspiration of membrane.

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: .,

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Language

English

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NONE

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Subject(s)

Anti Infectives

Specific Detail Info

IOSR Journal of Dental and Medical Sciences Volume 15, Issue 8 Ver. III (August. 2016), PP 71-76

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