PRODUCT LITERATURE

Investigation of prion removal/inactivation from chromatographic gel

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Concerns about the potential for prions to be retained on chromatography gels during the manufacture of plasma products prompted development of an investigational strategy for detecting infectious prions bound to gels. The objective was to firstly examine methods of implanting gels intracerebrally (IC) in mice, then to examine prion cleaning from a scaled-down version of the DEAE Sepharose column used in a production process to fractionate immunoglobulins and albumin from human plasma.

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Albapure

Specific Detail Info

Vox Sanguinis (2006) 91 , 301–308

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