PRODUCT LITERATURE

Prion-removal capacity of chromatographic and ethanol precipitation steps used in the production of albumin and immunoglobulins

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Although there is no epidemiological evidence to suggest that classical Creutzfeldt–Jakob disease (CJD) is transmitted through blood or blood products, the variant form (vCJD) has been implicated in transmission via packed red blood cells. The potential threat of the infectious agent contaminating plasma pools has led to manufacturing processes being examined for capacity to remove prions. The objective of these studies was to examine the prion-removal potential of the chromatographic purification and ethanol precipitation steps used to fractionate immunoglobulins and albumin from human plasma

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Detail Information

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: .,

Collation

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Albapure

Specific Detail Info

Vox Sanguinis (2006) 91, 292–300

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