No image available for this title

LITERATURE

Comparison of the post-antibiotic effect (PAE) induced by ceftizoxime, ceftriaxone, cefoxitin, ampicillin–sulbactam, and ticarcillin–clavulanate against selected isolates of Bacteroides fragilis and B. thetaiotaomicro


The exposure of bacteria to various groups of antimicrobials at different concentrations can produce damage to the bacteria that
persists even after removal of the antimicrobial agent. The post antibiotic effect (PAE) of b-lactams on aerobic Gram-negative
bacilli is relatively short (o1 h), however, little information is available regarding anaerobic Gram-negative bacilli. We studied the
PAE of ceftizoxime, ampicillin–sulbactam, ticarcillin–clavulanate, cefoxitin, and ceftriaxone against strains of Bacteroides fragilis
and B. thetaiotaomicron at antimicrobial concentrations 4, 8, and 16 the MIC values using colony count determinations of
treated and untreated cultures. Against B. fragilis H931, ceftizoxime-induced PAE values were 2 h, 3 h 24 min, and 11 h 36 min at
4MIC, 8MIC, and 16MIC while for the B. thetaiotaomicron isolates PAEs ranged from 2 h 27 min to 6 h 12 min at the same
concentrations.


Availability

Tizos-001Titan CenterAvailable

Detail Information

Series Title
-
Call Number
-
Publisher : .,
Collation
-
Language
English
ISBN/ISSN
-
Classification
NONE
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Specific Detail Info
Anaerobe 8 (2002) 295–299
Statement of Responsibility

Other version/related

No other version available


File Attachment



Information


RECORD DETAIL


Back To Previous