PRODUCT LITERATURE

Comparison of the post-antibiotic effect (PAE) induced by ceftizoxime, ceftriaxone, cefoxitin, ampicillin–sulbactam, and ticarcillin–clavulanate against selected isolates of Bacteroides fragilis and B. thetaiotaomicro

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The exposure of bacteria to various groups of antimicrobials at different concentrations can produce damage to the bacteria that
persists even after removal of the antimicrobial agent. The post antibiotic effect (PAE) of b-lactams on aerobic Gram-negative
bacilli is relatively short (o1 h), however, little information is available regarding anaerobic Gram-negative bacilli. We studied the
PAE of ceftizoxime, ampicillin–sulbactam, ticarcillin–clavulanate, cefoxitin, and ceftriaxone against strains of Bacteroides fragilis
and B. thetaiotaomicron at antimicrobial concentrations 4
, 8
, and 16
the MIC values using colony count determinations of
treated and untreated cultures. Against B. fragilis H931, ceftizoxime-induced PAE values were 2 h, 3 h 24 min, and 11 h 36 min at
4
MIC, 8
MIC, and 16
MIC while for the B. thetaiotaomicron isolates PAEs ranged from 2 h 27 min to 6 h 12 min at the same
concentrations.

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Tizos

Specific Detail Info

Anaerobe 8 (2002) 295–299

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