THERAPEUTIC CLASS

Metformin and metabolic diseases: a focus on hepatic aspects

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Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2
diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production
(HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically,
metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a
pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia,
metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D.

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: .,

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Language

English

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NONE

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Subject(s)

Glumin
Endocrine & Metabolic system
GLUMIN XR
Diabemin
Diabemin XR

Specific Detail Info

Front. Med.

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