THERAPEUTIC CLASS
Targeted Therapy as an Alternative to Whole-Brain Radiotherapy in EGFR-Mutant orALK-Positive Non–Small-Cell Lung Cancer With Brain Metastases
Patients with advanced EGFR-mutant or ALK-positive non–smallcell lung cancer (NSCLC) have a high cumulative risk (>70%) for developing brainmetastases (BrM) during the course of their disease. Recently, an update of the graded prognostic assessment (GPA) for patients with NSCLCandBrMhas established that molecular alterations in EGFR or ALK are an independent prognostic factor for betteroutcomes.
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