THERAPEUTIC CLASS

Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria

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There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics. Antibody concentrations were quantified by ELISA and anti-toxin neutralizing activity by cytotoxicity assay in serum from 4 patients receiving DAT for suspected diphtheria. Using linear mixed effects modeling, estimated mean (SE) half-life was 78.2 (20.0) hours. Maximum serum neutralizing activity ranged from 28.42–38.64 AU/mL with an estimated mean AUC1–72 of 1396.7 (399.3)
AU/mL
hr. These data provide a standard of comparison for development of novel anti-toxins to replace DAT

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: .,

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Language

English

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NONE

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Subject(s)

Allergy & Immune System

Specific Detail Info

HUMAN VACCINES & IMMUNOTHERAPEUTICS 2017, VOL. 13, NO. 11, 2738–2741

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