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LITERATURE

A Review of Doripenem for the Treatment of Serious Bacterial Infections


Doripenem is a carbapenem bactericidal agent that demonstrates in vitro activity against a wide variety of Gram-negative
and Gram-positive pathogens. In vitro data show that doripenem combines the intrinsic activity of meropenem against Gram-negative
pathogens with the intrinsic activity of imipenem against Gram-positive pathogens. The availability of doripenem is particularly welcome
in the current setting of increased resistance among Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter species, and extended-spectrum β-lactamase-producing Enterobacteriaceae


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English
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NONE
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Specific Detail Info
Clinical Medicine Reviews in Therapeutics 2010:2 201–227
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