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Comparative Effectiveness and Safety of Cefdinir and Amoxicillin-Clavulanate in Treatment of Acute Community-Acquired Bacterial Sinusitis


Cefdinir is an extended-spectrum oral cephalosporin that is active against pathogens commonly seen in acute community-acquired bacterial sinusitis (ACABS), including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Two randomized, investigator-blind, multicenter trials (one in the United States and one in Europe) compared two dosage regimens of cefdinir (600 mg once a day for 10 days and 300 mg twice a day for 10 days) to amoxicillin-clavulanate (A-C) (500 mg three times a day for 10 days) for adult and adolescent patients with ACABS


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English
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NONE
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, July 1997, p. 1517–1520
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