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LITERATURE

The Pathogenesis of Lupus Nephritis


Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear autoantigens. This loss of tolerance becomes clinically detectable by the presence of antinuclear antibodies


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REQJ553-03Titan CenterAvailable

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English
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NONE
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J Am Soc Nephrol 24: 1357–1366, 2013
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