THERAPEUTIC CLASS

The Pathogenesis of Lupus Nephritis

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Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear autoantigens. This loss of tolerance becomes clinically detectable by the presence of antinuclear antibodies

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: .,

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Language

English

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NONE

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Subject(s)

Allergy & Immune System

Specific Detail Info

J Am Soc Nephrol 24: 1357–1366, 2013

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