THERAPEUTIC CLASS
Serum Levels of FGF21 and Prediction of Cardiovascular Events
Over the last decade, the discovery of endocrine fibroblast growth factors (eFGFs) and their signaling pathways with regulatory functions in cell metabolism, but not proliferation, is among the major breakthroughs in the field of endocrinology and metabolism [1, 2]. Among eFGFs, FGF21 has attracted much attention as a potential pharmacotherapy against major metabolic diseases, such as obesity, diabetes, fatty liver disease, cardiometabolic diseases, and collateral tissue damage, as demonstrated in both animal models and human clinical patients [3–5].
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