PRODUCT LITERATURE

Evaluation of Pefloxacin in Experimental Escherichia coli Meningitis

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Pefloxacin mesylate, a new fluoroquinolone, has been shown to have a wide spectrum of activity both in vitro and in vivo (4, 8, 12, 13). Because of its excellent activity against members of the family Enterobacteriaceae and because in vitro tests may not reliably predict the bactericidal activity of a drug against meningitis (9), we evaluated the therapeutic efficacy of pefloxacin with a well-standardized rabbit model of Escherichia coli meningitis. The specific purposes of this investigation were to determine the percent penetration of pefloxacin into the cerebrospinal fluid (CSF) and to compare the in vivo efficacy of the drug with those of cefotaxime and chloramphenicol.

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: .,

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Dexaflox

Specific Detail Info

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Mar. 1986, p. 409-411

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