PRODUCT LITERATURE

Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity in Type 2 Diabetic Patients

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We examined the effect of pioglitazone on abdominal fat distribution to elucidate the mechanisms via which pioglitazone
improves insulin resistance in patients with type 2 diabetes mellitus. Thirteen type 2 diabetic patients (nine men and four
women; age, 52
3 yr; body mass index, 29.0
1.1 kg/m2), who were being treated with a stable dose of sulfonylurea (n  7)
or with diet alone (n  6), received pioglitazone (45 mg/d) for 16 wk. Before and after pioglitazone treatment, subjects underwent a 75-g oral glucose tolerance test (OGTT) and two step euglycemic insulin clamp (insulin infusion rates, 40 and
160 mU/m2
min) with [3H]glucose

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Deculin

Specific Detail Info

The Journal of Clinical Endocrinology & Metabolism 87(6):2784–2791

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