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LITERATURE

Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity in Type 2 Diabetic Patients


We examined the effect of pioglitazone on abdominal fat distribution to elucidate the mechanisms via which pioglitazone
improves insulin resistance in patients with type 2 diabetes mellitus. Thirteen type 2 diabetic patients (nine men and four
women; age, 52  3 yr; body mass index, 29.0  1.1 kg/m2), who were being treated with a stable dose of sulfonylurea (n  7)
or with diet alone (n  6), received pioglitazone (45 mg/d) for 16 wk. Before and after pioglitazone treatment, subjects underwent a 75-g oral glucose tolerance test (OGTT) and two step euglycemic insulin clamp (insulin infusion rates, 40 and
160 mU/m2min) with [3H]glucose


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English
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NONE
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The Journal of Clinical Endocrinology & Metabolism 87(6):2784–2791
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