PRODUCT LITERATURE

Chitosan-catechol: A polymer with long-lasting mucoadhesive properties

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Numerous mucoadhesive polymers have been exploited for prolonging the residence time of formulated drugs or pharmaceuticals at specific delivery sites. However, it has been difficult to achieve satisfactory mucoadhesive properties. The two major modification strategies such as thiolation or lectin functionalization have been extensively studied, but disulfide bond reversibility in the case of thiolation and the toxicity of lectins have been problems. Thus, approaches for further improvement of mucoadhesive properties need to be developed. With an overwhelming library of mucoadhesive
polymers, one practical way to improve mucoadhesion is chemical modification of existing mucoadhesive
polymers.

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: .,

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Language

English

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NONE

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Subject(s)

Mediclore

Specific Detail Info

Biomaterials 52 (2015) 161e170

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