THERAPEUTIC CLASS

Thiamphenicol Induced Bone Marrow Suppression as a Therapy of Myeloproferative Diseases

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Sixteen patients, suffering from myeloproliferative diseases (9 polycythaemia vera, 7 primary thrombocythaemia) and 20 control subjects were treated for 14 days with 1 g of thiamphenicol per day. The effect of 40 treatment cycles was studied. The regimen resulted in lowering the haemoglobin values by 4.8070 in controls (p >_ 0.001) and patients (p >_ 0.01); the reticulocyte count dropped 43 °70 in the patient group (p _> 0.01) and 32070 in the controls (p _> 0.05); the thrombocyte
count was decreased 42070 (p _> 0.0001) vs 29070 (p _> 0.0001) in the control group. The administration of 1 g/day of thiamphenicol for a 14 day period reduced the
myelopoietic activity by 40070. The decrease of all values was statistically significant. After discontinuation of thiamphenicol therapy the haematological parameters
returned to the initial values within 1-2 months. The myelodepressant activity of thiamphenicol may therefore be applied to the therapy of the myeloproliferative
diseases in order to reduce the risk of spontaneous haemorrhages and thrombosis.

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: .,

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Language

English

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Classification

NONE

Content Type

LITERATURE

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Subject(s)

Fonkozomib
Oncology

Specific Detail Info

Blut (1984) 49:457-463

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