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Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis : The ASTEROID Trial

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Very high-intensity statin therapy using rosuvastatin 40 mg/d achieved an average LDL-C of 60.8 mg/dL and increased HDL-C by 14.7%, resulting in significant regression of atherosclerosis for all 3 prespecified IVUS measures of disease burden. Treatment to LDL-C levels below currently accepted guidelines, when accompanied by significant HDL-C increases, can regress atherosclerosis in coronary disease patients. Further studies are needed to determine the effect of the observed changes on clinical outcome

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: .,

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Language

English

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NONE

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Subject(s)

Cholestor

Specific Detail Info

JAMA. 2006;295

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