Image of Novel insights into acute kidney injuryechronic kidney disease continuum and the role of renineangiotensin system

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Novel insights into acute kidney injuryechronic kidney disease continuum and the role of renineangiotensin system


Acute kidney injury (AKI) is an independent risk factor for chronic kidney disease (CKD). If injury is mild, a repair process can be adaptive and lead to complete renal recovery. However, severe injury will be accompanied by a maladaptive repair which usually leads to nephron loss, fibrosis, vascular rarefaction, and chronic inflammation. Although various mechanisms underlying AKI-CKD transition have been explored, no intervention has been proved effective to block the transition until very recently


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English
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NONE
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Journal of the Formosan Medical Association (2017) xx, 1e8
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