THERAPEUTIC CLASS

Update on Angiotensin II : New Endocrine Connections between the Brain, Adrenal Glands and the Cardiovascular System

---

In the brain, angiotensinergic pathways play a major role in chronic regulation of cardiovascular and electrolyte homeostasis. Increases in plasma angiotensin II (Ang II), aldosterone, [Na+] and cytokines can directly activate these pathways. Chronically, these stimuli also activate a slow neuromodulatory pathway involving local aldosterone, mineralocorticoid receptors (MRs), epithelial sodium channels, and endogenous ouabain (EO). This pathway increases AT1R and NADPH oxidase subunits, and maintains/further increases activity of angiotensinergic pathways.

---

Availability

Detail Information

Series Title

-

Call Number

-

Publisher

: .,

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

Society for Endocrinology and European Society of Endocrinology. 2017

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment