THERAPEUTIC CLASS

Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update

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The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular volume homeostasis and blood pressure through complex mechanisms. Apart from the well known systemic RAS, occurrence of a local RAS has been documented in multiple tissues, including the kidney. A large body of recent evidence frompharmacologic and genetic studies, particularly those using various transgenic approaches to manipulate intrarenal levels of RAS components, has established the important role of intrarenal RAS in hypertension

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: .,

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Language

English

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NONE

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Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

J Am Soc Nephrol 2017;28:

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