THERAPEUTIC CLASS

Effect of Chloramphenicol and Thiamphenicol on the In Vitro Colony-forming Cell

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STRONG EVIDENCE HAS been provided to indicate that chloramphenicol-(CAP) induced reversible bone marrow suppression results from inhibition of mitochondrial protein synthesis and consequent mitochondrial injury. ı Suppression of ferrochelatase activity, a mitochondrial-membraneassociated enzyme, with a block in the last step of heme synthesis has been suggested as a basis for the apparent vulnerability of the erythroid precursors to CAP.4’5

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Detail Information

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Publisher

: .,

Collation

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Oncology
Fonkozomib

Specific Detail Info

Blood, Vol. 43, No. 3 (March), 1974

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