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Effect of Chloramphenicol and Thiamphenicol on the In Vitro Colony-forming Cell


STRONG EVIDENCE HAS been provided to indicate that chloramphenicol-(CAP) induced reversible bone marrow suppression results from inhibition of mitochondrial protein synthesis and consequent mitochondrial injury. ı Suppression of ferrochelatase activity, a mitochondrial-membraneassociated enzyme, with a block in the last step of heme synthesis has been suggested as a basis for the apparent vulnerability of the erythroid precursors to CAP.4’5


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English
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NONE
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Blood, Vol. 43, No. 3 (March), 1974
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