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Anaemia in kidney disease: harnessing hypoxia responses for therapy


Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of novel therapeutic agents for its treatment. Hypoxia-inducible factor (HIF)‑2 is a key regulator of erythropoiesis and iron metabolism. HIF‑2 is activated by hypoxic conditions and controls the production of erythropoietin by renal peritubular interstitial fibroblast-like cells and hepatocytes


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English
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Nature Reviews Nephrology
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