THERAPEUTIC CLASS

Anaemia in kidney disease: harnessing hypoxia responses for therapy

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Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of novel therapeutic agents for its treatment. Hypoxia-inducible factor (HIF)‑2 is a key regulator of erythropoiesis and iron metabolism. HIF‑2 is activated by hypoxic conditions and controls the production of erythropoietin by renal peritubular interstitial fibroblast-like cells and hepatocytes

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: .,

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Language

English

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NONE

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Therapeutic Class

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NESP
Cardiovascular & Hematopoietic System

Specific Detail Info

Nature Reviews Nephrology

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