THERAPEUTIC CLASS

Overview of P-glycoprotein inhibitors: a rational outlook

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P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette
(ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It
is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resistance is induced because of the protein efflux.

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: .,

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Language

English

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NONE

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Edition

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Subject(s)

Gastrointestinal & Hepatobiliary System

Specific Detail Info

Brazilian Journal of Pharmaceutical Sciences vol. 48, n. 3, jul./sep., 2012

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