Image of Overview of P-glycoprotein inhibitors: a rational outlook

LITERATURE

Overview of P-glycoprotein inhibitors: a rational outlook


P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette
(ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It
is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resistance is induced because of the protein efflux.


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English
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NONE
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Brazilian Journal of Pharmaceutical Sciences vol. 48, n. 3, jul./sep., 2012
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