THERAPEUTIC CLASS

Eosinophil trafficking in allergy and asthma

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Blood eosinophilia and tissue eosinophilia are characteristic features of allergic inflammation and asthma, conditions associated with prominent production of TH2 cytokines IL-4, IL-5, and IL-13. In this review, we will consider recent advances in our understanding of the molecular mechanisms that promote expansion and differentiation of eosinophil progenitors in bone marrow, eosinophil recruitment in response to chemokine receptor 3 agonists eosinophil transit
mediated by specific ligand-receptor interactions, and prolonged survival of eosinophils in peripheral tissues. Novel rational therapies including antiselectin and antichemokine
receptor modalities designed to block eosinophil development and trafficking are discussed, together with the implications of recent clinical studies that have evaluated the efficacy of
humanized anti–IL-5 mAb therapy

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: .,

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Language

English

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NONE

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Subject(s)

Allergy & Immune System

Specific Detail Info

J Allergy Clin Immunol 2007;119:1303-10

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