THERAPEUTIC CLASS

Kidney and hypertension

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There is a unique relationship be- the ultimate determinant of BP must be renal handling
tween the kidney and blood pressure (BP): on the one hand, of sodium according to this concept. This does not imply
rcerenaaslediynsBfuPn,cwtiohnileaonndtphaerotitchuelrarhlaynrde,nhailghdiBsePasaecccealeursaeteasnloinss- that hypertension (HT) is a renal disease, but indicates
of function of the diseased kidney. Transplantation studies, that a renal functional abnormality, i.e. disturbed BP/
both in experimental animals and humans, documented that natriuresis relationship, is a sine-qua-non condition for
“blood pressure goes with the kidney,” a normotensive recipi- the development of any type of HT.
ent of a kidney genetically programmed for hypertension (HT) Early studies of Bianchi et al [2] and more definite
will develop HT, while conversely hypertensive patients with
renal failure receiving the kidney of a normotensive donor well controlled experimental studies of Rettig et al [3, 4]
may develop normotension.

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Genito -Urinary System

Specific Detail Info

Kidney International, Vol. 61, Supplement 80 (2002), pp. S62–S67

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