THERAPEUTIC CLASS

Photosensitive epilepsy : Robust clinical efficacy of a selective GABA potentiator

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The objective of this phase 2a study was to assess the activity of PF-06372865, a positive
allosteric modulator (PAM) of α2/3/5 subunit-containing GABAA receptors with minimal
activity at α1-containing receptors, which are believed to mediate many of the adverse events
associated with benzodiazepines, in the epilepsy photosensitivity model as a proof-of-principle
of efficacy

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Gabapentin
Valproic acid
Central Nervous System
Pregabalin

Specific Detail Info

Neurology 2019

Statement of Responsibility

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