PRODUCT LITERATURE

Local and Systemic Safety of Intranasal Corticosteroids

---

The safety and effi cacy of intranasal corticosteroids (INCs) are well established for the management of allergic rhinitis, rhinosinusitis, and nasal polyps. As seen in numerous studies, INCs demonstrate markedly reduced systemic bioavailability compared with oral and even
inhaled corticosteroids and have shown an excellent safety profi le over 3 decades of use. Nonetheless, concerns remain among some prescribers and patients that these agents may reach the systemic circulation in suffi cient concentration to produce adverse effects (AEs).
Available evidence does not support these concerns. A review of the published literature indicates that the side effect profi les of INCs consist primarily of a low incidence of mostly mild and often transient local AEs, such as nasal irritation and epistaxis.

---

Availability

Detail Information

Series Title

-

Call Number

-

Publisher

: .,

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Modexa
Intranasal Corticosteroids

Specific Detail Info

J Investig Allergol Clin Immunol 2012; Vol. 22(1): 1-12

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment