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Local and Systemic Safety of Intranasal Corticosteroids


The safety and effi cacy of intranasal corticosteroids (INCs) are well established for the management of allergic rhinitis, rhinosinusitis, and nasal polyps. As seen in numerous studies, INCs demonstrate markedly reduced systemic bioavailability compared with oral and even
inhaled corticosteroids and have shown an excellent safety profi le over 3 decades of use. Nonetheless, concerns remain among some prescribers and patients that these agents may reach the systemic circulation in suffi cient concentration to produce adverse effects (AEs).
Available evidence does not support these concerns. A review of the published literature indicates that the side effect profi les of INCs consist primarily of a low incidence of mostly mild and often transient local AEs, such as nasal irritation and epistaxis.


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English
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NONE
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J Investig Allergol Clin Immunol 2012; Vol. 22(1): 1-12
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